LB903 Association of atopic dermatitis and behavioral problems in childhood

Atopic dermatitis (AD) in children has been linked to neuropsychiatric disorders, such as depression, anxiety and attention deficit hyperactivity disorder, well impairments conduct, emotions learning. However, the direct impact of AD on behavior not rigorously examined date. Using a birth cohort U.S. enrolled Study Early Child Care Youth Development from 1991 2007, we conducted longitudinal study comparing 116 with 1,104 without respect outcomes measured by caregiver-reported Behavior Checklist (CBCL), widely-used rating scale, at 9 timepoints between 24 months 15 years old. was assessed 36 age, 54 months, 1st grade, caregiver report ≥2 points used define presence AD. generalized estimating equations adjusted for sex, race/ethnicity, gestational parental education, family income, significantly associated clinically concerning behavioral problems (t-score ≥70) internalizing (OR 2.07 [95% CI 1.03-4.16]), externalizing 3.26 [1.20-8.84]), total 2.92 [1.38-6.20]). Among individual CBCL scales, most highly aggressive 2.72 [1.08-6.86]), somatic complaints 2.65 [1.53-4.56]), anxious/depressed symptoms 2.45 [0.89-6.75]), delinquent 2.17 [0.89-5.31]). Sensitivity analyses alternative definitions led similar results. Our findings suggest that is higher odds significant during childhood, after adjustment key sociodemographic characteristics, underscoring psychosocial burden families. Further work needed screen characterize those greatest risk implement age-appropriate interventions address their needs